ea0042p42 | (1) | Androgens2016
Djusberg Erik
, Jernberg Emma
, Thysell Elin
, Golovleva Irina
, Lundberg Pia
, Crnalic Sead
, Widmark Anders
, Bergh Anders
, Brattsand Maria
, Wikstrom Pernilla
The relation between androgen receptor (AR) gene amplification and other mechanisms behind castration-resistance in prostate cancer, such as increased expression of constitutively active AR variants and steroid-converting enzymes have been poorly examined. Specific aims of this study were to examine AR amplification in treatment-naïve and castration-resistant prostate cancer (CRPC) bone metastases and to explore molecular and functional differences. AR gene amplification ...